Title of article :
Rosai-Dorfman Disease with nodal and extranodal involvements: A case report
Author/Authors :
Najafi-Sani, Mehri Associate Professor of Pediatric Gastroenterology - Department of Pediatrics, Tehran University of Medical Sciences , Saneian, Hossein Assistant Professor - of Pediatric Gastroenterology - Department of Pediatrics, Isfahan University of Medical Sciences , Mahjoub, Fatemeh Associate Professor of Pathology - Department of Pathology, Tehran University of Medical Sciences
Abstract :
Rosai-Dorfman disease (RDD) is a rare lymphoproliferative disorder with nodal and extranodal involvements. Here we
report a case of RDD in a 15-year-old female who presented with epigastric pain, fatigue, Raynaud phenomenon in fingers,
submandibular lymphadenopathy, proptosis, hepatosplenomegaly, and round shape painless patches on the extensor
surfaces. Histological examination of the submandibular lymph nodes and skin biopsy demonstrated evidences of
RDD. Patient was treated with prednisone and thereafter, with azathioprine. After one year, prednisone was discontinued
and all of the symptoms and signs, except proptosis, were resolved. This report highlights the extranodal manifestations
of RDD. The presentation, differential diagnosis, and treatment are discussed
Keywords :
Rosai-Dorfman Disease , Sinus Histiocytosis , Lymphadenopathy
Journal title :
Astroparticle Physics
