Author/Authors :
Dabbagh, Ali Fellowship in Cardiac Anesthesiology - Anesthesiology Research Center - Shahid Beheshti University of Medical Sciences, Tehran, , Farkhondehkish Moghadam, Shervin Shahid Beheshti University of Medical Sciences, Tehran , Rajaei, Samira Neuroscience Research Center - Shahid Beheshti University of Medical Sciences , Mansouri, Zahra Neuroscience Research Center and Department of Physiology - School of Medicine , Shardi Manaheji, Homa Neuroscience Research Center and Department of Physiology - School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran,
Abstract :
BACKGROUND: Chronic opium exposure leads to altered response to opioid compounds. The aim of this study was to
assess the behavioral effects of opium tolerance on the analgesic effects of intrathecal lidocaine in rats.
METHODS: Twenty-four adult male Sprague Dawley rats with intrathecal (IT) catheters were divided into 3 groups of 8.
The first group was morphine tolerant and received IT lidocaine (ML). Rats in the second group were not morphine
tolerant and received IT lidocaine (L), while the third group consisted of not morphine tolerant rats that received IT
placebo. Tail flick test was done and maximal possible antinociceptive effects (MPAE) were compared using analysis
of variance (ANOVA).
RESULTS: While percent of MPAE significantly increased in the L group, it had a significant reduction in the ML group
(P < 0.001).
Keywords :
Morphine , Intrathecal , Lidocaine , Local Anesthetic
