Author/Authors :
Nakayama, Satoshi Department of Laboratory Medicine - National Defense Medical College Hospital - Tokorozawa, Japan , Oda, Tomohiro Department of Laboratory Medicine - National Defense Medical College Hospital - Tokorozawa, Japan , Minabe, Shinya Department of Laboratory Medicine - National Defense Medical College Hospital - Tokorozawa, Japan , Bamba, Yukiharu Department of Laboratory Medicine - National Defense Medical College Hospital - Tokorozawa, Japan , Ukawa, Haruko Department of Laboratory Medicine - National Defense Medical College Hospital - Tokorozawa, Japan , Sato, Rika Department of Laboratory Medicine - National Defense Medical College Hospital - Tokorozawa, Japan , Kawabata, Masaki Department of Laboratory Medicine - National Defense Medical College Hospital - Tokorozawa, Japan , Horiuchi, Toshikatsu Department of Internal Medicine - National Defense Medical College - Tokorozawa, Japan , Watanabe, Junichi Department of Internal Medicine - National Defense Medical College - Tokorozawa, Japan , Kimura, Fumihiko Department of Internal Medicine - National Defense Medical College - Tokorozawa, Japan , Shimazaki, Hideyuki Department of Laboratory Medicine - National Defense Medical College Hospital - Tokorozawa, Japan , Ogata, Sho Department of Laboratory Medicine - National Defense Medical College Hospital - Tokorozawa, Japan , Nakanishi, Kuniaki Department of Laboratory Medicine - National Defense Medical College Hospital - Tokorozawa, Japan
Abstract :
Primary nonsecretory plasma cell leukemia (PCL) is an extremely rare type of multiple myeloma. Here, we report a case of nonsecretory PCL with no previous history of multiple myeloma. The case exhibited extremely low levels of serum immunoglobulin and light chain, no detectable serum M-protein or free light chain restriction, no urine BJP, and no cytoplasmic light chain expression in flow cytometry. In fluorescence in situ hybridization, tumor cells exhibited fusion genes for IgH/BCL1 and IgH/c-Myc, disappearance of the p53 signal, and a split signal for IgK(2p11), but no split signal for IgL (22q11). Therefore, we diagnosed primary nonsecretory PCL with multiple chromosomal abnormalities.
