Title of article :
Effects of melatonin on left ventricular ejection fraction and functional class of patients with heart failure: A randomized, double-blind, placebocontrolled trial
Author/Authors :
Garakyaraghi, Mohammad Associate Professor, Department of Cardiology and Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences Isfahan , Siavash, Mansour Associate Professor, Department of Endocrinology and Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan , Alizadeh, Mohammad Kazem Resident, Department of Cardiology, School of Medicine and Student Research Committee, Isfahan University of Medical Sciences, Isfahan
Abstract :
Melatonin, a hormone secreted by the pineal gland, has multiple effects on circadian physiology, blood pressure, and
coronary blood flow. It has also free radical scavenger and anti-oxidative activity. This study was planned to evaluate the effects of melatonin
on left ventricular function of patients with heart failure. METHODS: In this randomized double-blind clinical trial, 60 patients
with heart failure (based on clinical and echocardiography findings) admitted to two hospitals in Isfahan, Iran in 2010 received 3 mg melatonin
or placebo for 2 months. New York Heart Association (NYHA) functional class and left ventricular ejection fraction (LVEF) in
each group, before and after the study were compared. Comparisons were also made between the two groups each step. The data was
analyzed by appropriate statistical methods. RESULTS: Overall, 60 patients (41 men and 19 women) participated in this study. LVEF
increased from 31.7 to 37.6 in the case group (p < 0.001) and from 34.1 to 35.2 in the control group (p = 0.420). NYHA functional class
improved only in the case group (p = 0.014 versus 0.317). CONCLUSIONS: This study revealed that melatonin may
Keywords :
Melatonin , Heart Failure , New York Heart Association , Left Ventricular Ejection Fraction
Journal title :
Astroparticle Physics
