Author/Authors :
Najafi , Mohammad Reza Associate professor, Department of Neurology - School of Medicine, Isfahan University of Medical Sciences, Isfahan , Abrishamkar, Saeed Professor - Department of Neurosurgery - School of Medicine, Isfahan University of Medical Sciences, Isfahan , Sonbolestan, Ali Student of Medicine, Isfahan Neuroscience Research Center and Student Research Committee, Isfahan University of Medical Sciences, Isfahan , Hamrah, Hadid Student of Medicine - School of Medicine and Student Research committee, Isfahan University of Medical Sciences, Isfahan
Abstract :
Traumatic brain injury (TBI) is known as one of the most important causes of mortality in middle-aged
population. The aim of this study was to evaluate the effects of gabapentin in improvement of consciousness level in these patients.
METHODS: This randomized clinical trial was performed in March 2008 to September 2009. A total number of 60 patients from
neurology clinics of Kashani Hospital (Isfahan, Iran) were randomly divided into two groups of 30 subjects as the case and control
groups. The groups were respectively treated with 300 mg gabapentin and placebo twice a day for two weeks. The
electroencephalogram (EEG), Glasgow Outcome Scale (GOS), and Glasgow Coma Scale (GCS) findings were evaluated in all
patients before and one week after the intervention. RESULTS: The mean values of GCS and GOS before and after the treatment
were not significantly different between the groups. This study showed significant changes in EEG patterns after treatment with
gabapentin. CONCLUSIONS: Gabapentin might not be suggested for management of unconsciousness due to TBI.
Keywords :
Gabapentin , Brain Injuries , Consciousness , Electroencephalography
