Author/Authors :
Pourmoghaddas, Zahra Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan , Sadeghi, Masoumeh Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical sciences, Isfahan , Hekmatnia, Ali Department of Radiology, Isfahan University of Medical Sciences, Isfahan , Sanei, Hamid Department of Cardiology, Isfahan University of Medical sciences, Isfahan , Tavakoli, Babak Department of Radiology, Student Research Committee, Isfahan University of Medical sciences, Isfahan , Roohafza, Hamidreza Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan , Sarrafzadegan, Nizal Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical sciences, Isfahan
Abstract :
Adipose tissue as an endocrine organ secretes adiponectin that is a cardiovascular atherosclerosis-modulating
factor. However, some studies showed that adiponectin reduces obesity. In the present study, adiponectin association with body mass
index (BMI), waist circumference (WC), visceral adipose tissue (VAT) and subcutaneous visceral tissue (SAT) as different measurements
of obesity were evaluated in patients with coronary heart disease (CHD). METHODS: Sixty-eight patients with CHD
were chosen using simple random sampling. Body weight, height, WC and blood pressure were measured. Fasting blood samples
were taken to assess fasting blood sugar, total cholesterol, triglyceride, low and high-density lipoproteins cholesterol. Patients underwent
an abdominal computerized scan (CTS) to detect VAT and SAT. Linear regression test used to assess the relation of different
measurements of the obesity with adiponectin adjusting for age, sex, hypertension, dyslipidemia, and diabetes mellitus.
RESULTS: The mean age of the study population was 50.5 ± 7.0. Females were 67.6% of study population. Multivariate analyses
showed the inverse association of waist-to-height ratio (WHtR) (β = -0.25, p = 0.03), WC (β = -0.24, p = 0.24) and visceral fat
(β = -0.32, p = 0.01) with adiponectin. CONCLUSIONS: WC and WHtR are simple proxy measures of obesity that better showed
adverse metabolic effect of visceral fat in patients with CHD.
Keywords :
Adiponectin , Coronary Heart Disease , Obesity , Intra-abdominal Fat , Waist Circumference , Waist-to-height Ratio
