Author/Authors :
Nilforoushzadeh, Mohammad Ali Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran and Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, , Jaffary, Fariba Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan , Ansari, Nazli Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan , Siadat, Amir Hossein Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan , Heidari, Asieh Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan , Adibi, Neda Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan
Abstract :
Despite using different treatment modalities, treatment of diabetic foot ulcer is still a very important challenge. In
this case series, we report successful treatment of 6 patients with resistant diabetic ulcers using topical application of trichloroacetic
acid (TCA). METHODS: Six patients with type 2 diabetes mellitus received standard treatment for 6 weeks. TCA 70% was applied
to the periphery of the ulcer while TCA 50% was applied to the center of the ulcer every week until the first significant reepithelialization
was observed. RESULTS: All wounds in all 6 treated patients were improved after a mean duration of 7.5 ± 0.83 weeks. In
fact, significant reductions were observed in the areas and infection scores of the ulcers. CONCLUSIONS: The range of improvement
efficacy ranged from 68.6% to 100% with no complications after 1, 2, and 3 months of follow-up. The observed efficacy of
TCA on diabetic ulcer healing is due to production of granulation tissue and epithelial cells.
