EFFECTS OF CAPSAICIN IN LOW DOSES an‎d HIGH DOSES ON THE SMALL INTESTINE MOTOR RESPONSE IN WILD-TYPE an‎d TRPV1 KNOCKOUT MICE (BRIEF COMMUNICATION)

Brief Communication Contractile activity of the small intestine is coordinated by interplay of myogenic, neural, and chemical controls. Both primary afferent neurons (extrinsic) and intrinsic enteric neurons are present in the small intestine and capsaicin (vanilloid, 8-methyl-N-vanillyl-6-noneamide), the pungent ingredient of chili peppers, specifically acts on extrinsic primary afferent but not intrinsic enteric neurons. The transient receptor potential V1 (TRPV1) or formerly known as VR1, is activated by capsaicin.