Author/Authors :
Zahiri Sorouri, Ziba Reproductive Health Research Center - Department of Obstetrics & Gynecology - Al-zahra Hospital - School of Medicine - Guilan University of Medical Sciences, Rasht , Pourmarzi, Davoud Reproductive Health Research Center - Gilan University of Medical Sciences, Rasht , Safar Khah, Niloufar Reproductive Health Research Center - Department of Obstetrics & Gynecology - Al-zahra Hospital - School of Medicine - Guilan University of Medical Sciences, Rasht
Abstract :
Background: The current treatment regimen for ovarian stimulation in Intracytoplasmic
sperm injection (ICSI) patients is daily injections of Gonadotropins. Recombinant DNA
technologies have produced a new recombinant molecule that is a long-acting Follicle
Stimulating Hormone (FSH), named corifollitropin alfa. A single injection of long-acting
FSH can replace seven daily FSH injections during the first week of controlled ovarian
stimulation (COS) and can make assisted reproduction more patients-friendly. There is
limited data with different results in this area.
Objective: To compare the effectiveness of long-acting FSH vs. daily r-FSH in terms of
pregnancy and safety outcomes in women undergoing ICSI cycles.
Materials and Methods: In this clinical trial study, 109 women who were the candidates
for ICSI at azzahra hospital were divided in two groups. The first group received
150 units of daily Gonal-f from second or third day of menstruation. The second
group received a 150IU corifollitropin alfa on the second or third day of mensuration,
and the treatment continued from day eighth of stimulation with Gonal-f based
on the ultrasound finding. Both the groups received GnRH antagonist from fifth
day of stimulation. Two groups were compared in terms of number of dominant
follicles, number of oocytes, stimulation duration, total number of embryos, number
of transferred embryos, and success rate of pregnancy.
Results: No significant difference was found between the two groups in terms of
stimulation duration, number of follicles, number of oocytes, total number of embryos,
and number of transferred embryos. Moreover, pregnancy outcomes including
chemical pregnancy rate (positive pregnancy test), clinical pregnancy rate (detection
of fetal heart), the rate of ovarian hyper-stimulation syndrome, multiple-pregnancy,
ectopic pregnancy, and miscarriage didn’t have a significant difference between the
two groups.
Conclusion: As corifollitropin alfa was as effective as r-FSH, it could be used as an
alternative to ovulation stimulation method in patients undergoing ICSI.
Keywords :
Corifollitropin alfa , Gonal-F , Pregnancies , r-FSH
