Title of article
Secondary Metabolites and Biological Activities of Talaromyces sp. LGT-2, an Endophytic Fungus from Tripterygium Wilfordii
Author/Authors
Zhao, Qiu-Hong School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou , Yang, Zhong-Duo School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou , Shu, Zong-Mei School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou , Wang, Yong-Gang School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou , Wang, Ming-Gang School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou
Pages
6
From page
453
To page
458
Abstract
In the present study, eleven compounds (1-11) including nine alkaloids (1-9), one triterpenoid
saponin (10) and one formamide (11) were isolated from Talaromyces sp. LGT-2, an endophytic
fungus from Tripterygium wilfordi. Their structures were determined based on NMR and ESIMS
spectral data, as well as comparing with previous literature data. This is the first report
of the isolation of alkaloids (1-9) from Talaromyces genus. In the next step, all compounds
were screened for their anti-monoamine oxidase, anti-acetylcholinesterase, antibacterial and
antitumor activities. Compound 11 showed moderate anti-monoamine oxidase activity with
IC50 value of 61 μM; compounds 3, 4, 8 showed weaker anti-acetylcholinesterase activity;
compounds 1, 3, 4, 7, 8, 9 showed moderate antibacterial activities; compounds 7, 8, 9 showed
cytotoxicity against B16 cancer cell line with inhibitory rate of 86%, 82%, 78%, respectively,
at the concentration of 500 μg/mL
Keywords
endophytic fungus , secondary metabolites , monoamine oxidase inhibition , Talaromyces , Tripterygium wilfordi
Journal title
Astroparticle Physics
Serial Year
2016
Record number
2446902
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