Author/Authors :
Filiz, Bakar Ankara University - Faculty of Pharmacy - Department of Biochemistry, 06100 Tandoğan, Ankara, Turkey , Karakay Ankara University - Faculty of Pharmacy - Department of Biochemistry, 06100 Tandoğan, Ankara, Turkey , Songül Ankara University - Faculty of Pharmacy - Department of Pharmaceutical Botany, 06100 Tandoğan, Ankara, Turkey , Bostanlık, Delimustafaoğlu Ankara University - Faculty of Pharmacy - Department of Pharmaceutical Botany, 06100 Tandoğan, Ankara, Turkey , Gül, Fatma Ankara University - Faculty of Pharmacy - Department of Pharmaceutical Botany, 06100 Tandoğan, Ankara, Turkey , Kılıç, Ceyda Sibel Ankara University - Faculty of Pharmacy - Department of Pharmaceutical Botany, 06100 Tandoğan, Ankara, Turkey
Abstract :
Ferulago W. Koch. (Apiaceae) genus is represented by approximately 50 taxa throughout
the world. Ferulago species are known as “Çakşır” or “Çağşır” in Turkey and mostly known for
their aphrodisiac effects. However recent reports emphasize the activity of various Ferulago
species against cancer, as well. The aim of this study was to investigate the effect of lyophilized
extract of F. mughlea Peşmen, a species endemic for Turkey, on cancer cell proliferation.
For this purpose human prostate (PC-3) and colorectal (SW-480) carcinoma cells were used
to evaluate the antiproliferative effects of Ferulago W. Koch and the measurements were
performed via MTT test. Lyophilized extracts obtained from aerial parts and the roots exhibited
potent inhibitor effects on cell proliferation. Aerial part of the plant inhibited the proliferation
of SW-480 cell at 48th hour with a 0.119 mg/mL IC50 value.
Keywords :
Ferulago mughlea , Apiaceae , lyophilized extract , antiproliferative , cancer , prostate , colorectal carcinoma
