Author/Authors :
Hani, Umme Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Sri Shivarathreeshwara Nagar, Mysore-570 015, Karnataka, India , Shivakumar, H.G. Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Sri Shivarathreeshwara Nagar, Mysore-570 015, Karnataka, India , Osmani, Riyaz Ali Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Sri Shivarathreeshwara Nagar, Mysore-570 015, Karnataka, India , Srivastava, Atul Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Sri Shivarathreeshwara Nagar, Mysore-570 015, Karnataka, India , Kumar Varma, Naga Sravan Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Sri Shivarathreeshwara Nagar, Mysore-570 015, Karnataka, India
Abstract :
The present investigation was designed to formulate a natural tablet for the treatment of
vaginal candidiasis in order to eliminate side effects that are caused by existing antifungal
drugs. Curcumin has promising antifungal activity in comparison with the existing azole
antifungal drugs. Bioadhesive curcumin vaginal tablets were prepared by direct compression
with different ratios of biadhesive polymers like xanthan gum, guar gum and HPMC. Curcumin
tablets were characterized by studies of friability, hardness, hydration, DSC, mucoadhesion,
In-vitro release and antifungal activity. DSC and FT-IR data indicate there was no interaction
between the drug and the excipients and also polymer concentration has some effects on
melting point of curcumin. Formulation F3 showed the best results in terms of swelling and
mucoadhesion together with prolonged drug release. The antifungal activity of the Curcumin
tablet has demonstrated a significant effect against Candida albicans. Hence, the study indicates
the possible and effective use of curcumin bioadhesive monolithic vaginal tablet for vaginal
candidiasis as a promising natural antifungal treatment
Keywords :
Curcumin , Bioadhesion , Vaginal tablets , Candidiasis
