Author/Authors :
Akbari chermini, Sadegh Young Researchers and Elite Club, Majlesi Branch, Islamic Azad University, Isfahan , Krimi, Hasan Department of Chemistry, Majlesi Branch, Islamic Azad University, Isfahan , Keyvanfard, Mohsen Department of Chemistry, Majlesi Branch, Islamic Azad University, Isfahan , Alizad, Khadijeh Department of Chemistry, Majlesi Branch, Islamic Azad University, Isfahan
Abstract :
The electrocatalytic oxidation of captopril (CAP) was studied by modified carbon
nanotubes paste electrode in the presence of isoproterenol (ISPT) using cyclic voltammetry
(CV), chronoamperometry and square wave voltammetry (SWV). Also, the values of catalytic
rate constant (k), and electron transfer coefficient (α) for CAP were calculated. The mechanism
of CA electrochemical behavior at the modified electrode surface was analyzed by various
electrochemical methods in the presence of mediator. The prepared modified electrode showed
voltammetric responses with high sensitivity for CAP, making it very suitable for the detection
of CAP at trace levels. Under the optimized conditions, the peak current was linear to CAP
concentration over the concentration range of 0.3 to 90 μmol L−1 using SWV. The detection
limit was 0.1 μmol L−1. The proposed method was successfully applied for the determination of
CAP in the urine, tablet and patient urine samples
Keywords :
Captopril , Isoproterenol , Multiwall carbon nanotubes , Sensor , Voltammetry
