Author/Authors :
El-serwy, Walaa Therapeutical Chemistry Department, National Research Center, Dokki, Cairo, Egypt , Mohamed, Neama Therapeutical Chemistry Department, National Research Center, Dokki, Cairo, Egypt , Kassem, Emad Therapeutical Chemistry Department, National Research Center, Dokki, Cairo, Egypt , Mahmoud, Khaled Department of Pharmacognosy, National Research Center, Cairo, Egypt. , Mounier, M Department of Pharmacognosy, National Research Center, Cairo, Egypt.
Abstract :
Different acid chlorides (2a-d) reacted with anthranilic acid to produce 2-substituted-3,
1-benzoxazin-4-one (3a-d) which was used as starting material to synthesize some condensed
and non-condensed heterocyclic compounds by reaction with nitrogen nucleophiles e.g.,
hydrazine hydrate and formamide. Some of the newly synthesized analogues were chosen to
evaluate their cytotoxic activity against human carcinoma cell lines (HePG2– MCF7– A549).
The docking and the cytotoxic activity results revealed that nearly all of the compounds
containing N-phenyl aniline showed significant inhibition for the three cell lines.
Keywords :
Cytotoxic activity , Benzoxazin , Quinazolin , Antitumor , Docking analysis
