Author/Authors :
Abdollahnejad, Fatemeh School of Traditional Medicine, Shahid Beheshti University of Medical Sciences , Mosaddegh, Mahmoud School of Traditional Medicine, Shahid Beheshti University of Medical Sciences , Nasoohi, Sanaz Department of Pharmacology and Toxicology - School of Pharmacy - Shahid Beheshti University of Medical Sciences, Tehran , Faizi, Mehrdad Department of Pharmacology and Toxicology - School of Pharmacy - Shahid Beheshti University of Medical Sciences, Tehran , Mirnajafi-Zadeh, Javad Deptartment of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran , Kamalinejad, Mohammad Department of Pharmacognosy - School of Pharmacy - Shahid Beheshti University of Medical Sciences
Abstract :
In this study, we investigated the sedative and hypnotic effects of the aqueous extract of
Aloe vera on rats. In order to evaluate the overall hypnotic effects of the Aloe vera extract, open
field and loss of righting reflex tests were primarily used. The sedative and hypnotic effects
of the extract were then confirmed by detection of remarkable raise in the total sleeping time
through analysis of electroencephalographic (EEG) recordings of animals. Analysis of the EEG
recordings showed that there is concomitant change in Rapid Eye Movement (REM) and None
Rapid Eye Movement (NREM) sleep in parallel with the prolonged total sleeping time. Results
of the current research show that the extract has sedative-hypnotic effects on both functional
and electrical activities of the brain
Keywords :
Aloe vera , Insomnia , Sedative-Hypnotic effects , Electroencephalography , Electromyography
