Cerium oxide nanoparticle modulates hepatic damage, inflammatory and oxidative stress biomarkers in a dose-dependent manner: an in vivo study of rat liver

Objective (s): Cerium oxide nanoparticles, nanoceria (CeNPs) is a novel nanoparticle that has great potential for the treatment of various diseases. This study aimed to investigate the effects of CeNPs on oxidative stress biomarkers in the liver of male rats. Materials and Methods: Twenty-four male Wistar rats were equally distributed into 4 groups (n=6/each). The first group was controlled and the next three groups received an intraperitoneal injection (IP) of CeNPs (15, 30 and 60 mg/kg/day) for 7 days. After treatment, serum and liver tissue were isolated. ALT and AST concentration, total antioxidant capacity (TAC), total thiol molecules (TTM), interleukin 17 (IL-17), nitric oxide (NO) and TNF-α were measured. Results: CeNPs 30, 60 mg/kg caused a significant increased in NO (P=0.03, P=0.001), TNF-α (P=0.03, P=0.01) and IL-17 (P=0.04, P=0.01) levels, compared with the control group. Also CeNPs caused a decrease in the TTM (P=0.002) and increased malondialdehyde (MDA) (P=0.04) in 60 mg/kg group compared to the control group. CeNPs at 15 mg/kg significantly suppressed the increase in plasma activities of aminotransferases (ALT (P=0.001), AST (P=0.01)), and liver IL-17 (P=0.01) and NO (P=0.02) concentrations compared to the control group.