Author/Authors :
Dalfardi, Mahsa Department of Anatomy - School of Medicine, Rafsanjan University of Medical Sciences , Dalfardi, Mahsa Department of Anatomy - School of Medicine, Rafsanjan University of Medical Sciences , Taghavi, Mohammad Mohsen Department of Anatomical Sciences, School of Medicine, Social Determinants of Health Research Center - Rafsanjan University of Medical Sciences, Rafsanjan , Kohbanani, Mahdi Shariati Department of Anatomical Sciences - School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan , Taghipour, Zahra Department of Anatomical Sciences - School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan , Nosratabadi, Reza Department of Immunology - School of Medicine, Kerman University of Medical Sciences, Kerman , Jalili, Cyrus Department of Anatomical Sciences - School of Medicine - Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah , Salahshoor, Mohammad Reza Department of Anatomical Sciences - School of Medicine, Kermanshah University of Medical Sciences, Kermanshah , Kaeidi, Ayat Department of Physiology and Pharmacology - School of Medicine - Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan , Shabanizadeh, Ahmad Department of Anatomical Sciences - School of Medicine - Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan
Abstract :
Objective (s): Silver nanoparticles (NPs) have attracted considerable attention owing to their important
properties, including antimicrobial and anti-oxidative stress effects. However, high concentrations of silver
NPs have been reported to have toxic effects. The present study aimed to evaluate the modulatory and
protective effects of royal jelly (RJ) against the harmful effects of silver NPs on hippocampal functions, such
as learning and memory.
Materials and Methods: This experimental study was conducted on 40 male Wistar rats. The animals were
divided into four groups of 10, including the control group (no silver NPs and RJ), RJ group, silver NPs plus
RJ, and silver NPs. Some functions of the hippocampus (e.g., learning and memory) were evaluated using
Morris memory function tests for four consecutive days. In addition, the relative expression of TRPV1 was
assessed using real-time polymerase chain reaction (RT-PCR). At the final stage, hippocampal tissues were
collected for histological studies.
Results: Levels of learning and memory, relative gene expression ratio of TRPV1, and the histological changes
in the hippocampus were significantly different in the groups receiving silver NPs compared to the groups
administered with RJ.
Conclusion: According to the results, RJ may be the effective in the protection against the adverse effects of
silver NPs and improve the function of the hippocampus
Keywords :
Hippocampus , Memory , Royal Jelly , Silver-nanoparticles , TRPV1
