Title of article :
Monomethyl Auristatin E, a Potent Cytotoxic Payload for Development of Antibody-Drug Conjugates against Breast Cancer
Author/Authors :
Abdollahpour-Alitappeh, Meghdad Immunology Department, Hybridoma Lab, Pasteur Institute of Iran, Tehran , Najminejad, Hamid Immunology Department, Hybridoma Lab, Pasteur Institute of Iran, Tehran , Abolhassani, Mohsen Immunology Department, Hybridoma Lab, Pasteur Institute of Iran, Tehran , Amanzadeh, Amir National Cell Bank of Iran, Pasteur Institute of Iran, Tehran , Heidarnejad, Fatemeh National Cell Bank of Iran, Pasteur Institute of Iran, Tehran , Habibi-Anbouhi, Mahdi National Cell Bank of Iran, Pasteur Institute of Iran, Tehran , Razavi-Vakhshourpour, Sepand Immunology Department, Hybridoma Lab, Pasteur Institute of Iran, Tehran , Lotfinia, Majid Department of Biochemistry, Pasteur Institute of Iran, Tehran , Jahandideh, Saeed Department of Biochemistry, Pasteur Institute of Iran, Tehran , Balalaie, Saeed Peptide Chemistry Research Group, K.N. Toosi University of Technology, Tehran
Pages :
6
From page :
98
To page :
103
Abstract :
Background: Breast cancer is a heterogeneous disease characterized by differential responses to targeted and chemotherapeutic agents. Antibody-drug conjugates are one of the promising strategies for the treatment of breast cancer. Monomethyl auristatin E (MMAE) is a highly potent microtubule inhibitor and a common payload used for development of antibody-drug conjugates. The purpose of this study was to investigate the cytotoxic effects of MMAE on breast cancer cell lines
Keywords :
Monomethyl auristatin E , cytotoxicity , Antibody-drug conjugate , MDA-MB-468 , MDA-MB-453
Journal title :
Astroparticle Physics
Serial Year :
2017
Record number :
2447132
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=2447132
بازگشت