Author/Authors :
Boskabady, M. H Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad , Kiani, S Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad , Jandaghi, P Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad , Ziaei, T Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad , Zarei, A Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad
Abstract :
Background: The relaxant and anticholinergic (functional antagonism)
effects, histamine H1 inhibitory effect, and calcium channel
blocking effect of Nigella sativa have been demonstrated on guinea
pig tracheal chains. Several therapeutic effects including antiasthma
and dyspnea have also been ascribed to the seeds of Nigella
sativa.
Objective: To evaluate the antitussive effect of this plant.
Methods: The antitussive effects of aerosols of two different concentrations
of aqueous and macerated extracts as well as an extract
of concentrated boiled seeds, codeine, and saline were tested by
counting the number of coughs produced 10 min after exposing animal
to aerosols of different solutions of citric acid (n=7 for each solution).
Results: The results showed significant reduction in the number of
coughs obtained in the presence of both concentrations of aqueous
and macerated extracts, boiled seeds extract and codeine (p<0.05 to
p<0.001). The cough number induced in the presence of higher concentrations
of aqueous and macerated extracts were also significantly
less than those with lower concentrations (p<0.05 for aqueous
and p<0.01 for macerated extracts). There was no significant difference
between the number of coughs obtained in the presence of all
extracts with that of codeine
Keywords :
Nigella sativa , guinea pigs , citric acid , codeine
