Author/Authors :
Kumar, V Department of Radiology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz , Hosseini, S.V Department of Radiology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz , Bagheri, M. H Department of Radiology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz , Izadpanah, A Department of Radiology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz , Yarmohammadi, H Department of Radiology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz , Mohammadi, A Department of Radiology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz
Abstract :
Background: One of the most serious late complications, after
evacuation of liver hydatid cyst and instillation of scolicidal agents
is sclerosing cholangitis, most probably caused by the type of scolicidal
agents instilled.
Objective: To determine the incidence of sclerosing cholangitis
after intra-biliary tract infusion of 5% saline and 0.5% silver nitrate.
Methods: 5% hypertonic saline and 0.5% silver nitrate were injected
trans-hepatically into the gallbladder of two equal groups
(n=15/group) of rabbits. 4 months later, the livers were biopsied and
cholangiography was performed, investigating for signs of sclerosing
cholangitis (SC).
Results: 30% of the rabbits in group A (hypertonic saline) and 80%
of group B (silver nitrate) developed SC. The prevalence of SC and
also the severity of pathological findings were significantly (p<0.05)
higher in group B (silver nitrate). 5% hypertonic saline seems to
cause a significant amount of sclerosis.
Conclusions: For treatment of hydatid cyst, intra-cystic injection of
5% hypertonic saline or 0.5% silver nitrate is not safe
Keywords :
Echinococcosis , sclerosing cholangitis , silver nitrate , hypertonic saline , Echinococcus granulosus , Iran
