Title of article :
Association of Hyperhomocysteinemia with Coronary Artery Disease in Southern Iran
Author/Authors :
Golbahar, J Division of Cardiology, Internal Medicine, Medical School, Shiraz University of Medical Sciences, Shiraz , Rezaian, G.R Division of Cardiology, Internal Medicine, Medical School, Shiraz University of Medical Sciences, Shiraz
Abstract :
Background: Differences in the prevalence and impact of hyperhomocytenemia
on vascular disease between countries and
races have been reported. Most studies have been undertaken
in North American and European populations and the importance
of plasma total homocysteine (tHcy) level as a risk factor
for coronary artery disease in the Middle East particularly in
Iran, however, is not known.
Objective: To determine the association of hyperhomocysteinemia
with coronary artery disease in Shiraz population, a
city in the South West of Iran.
Method: A case-control study was conducted in 195 men with
angiographically defined coronary artery disease and 201
healthy controls. Plasma tHcy concentrations were analyzed in
baseline samples by high performance liquid chromatography.
Results: Geometric mean of plasma tHcy was significantly
higher in patients (10.6±5.2 mmol/l) than in control (7.9±3.1
mmol/l) group (p<0.001). Comparing the top fifth (quintile), of
the plasma tHcy distribution to the bottom fifth, the adjusted
odds ratio of coronary artery disease was 2.3 (95% CI 1.0–5.5)
and there was a positive trend of increasing risk across quintiles
of the plasma tHcy distribution (p=0.02).
Conclusion: High plasma tHcy is associated with coronary
artery disease in Iranians living in Shiraz
Keywords :
Homocysteine , coronary artery disease , Shiraz
Journal title :
Astroparticle Physics
