Author/Authors :
Houshdar Tehrani, Mohammad Hassan Department of Pharmaceutical Chemistry, School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services, Tehran , Farnia, Farnoush Department of Pharmaceutical Chemistry, School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services, Tehran , Emami, Maryam Department of Pharmaceutical Chemistry, School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services, Tehran
Abstract :
Impurities of drug substances may produce some side effects in patient. Diclofenac Na is a
member of non-steroidal anti inflammatory drugs (NSAIDs) family, which is routinely used by
patients for the treatment of rheumatoid arthritis and various pains. To develop a method for the
determination of synthetic precursors which could be remained as impurities in raw drug
materials, Na diclofenac powder was chosen in this study. High performance liquid
chromatography was used to detect and separat e diclofenac from its usual precursors. The
chromatographic conditions were as follows: column; C18, mobile phase; methanol/water
(55/45), flow rate; 1 ml/min, wavelength of detector; 254nm. The chromatogram obtained
showed a reasonabl e separations of Na di clofenac and its precursors. This method of analysis is
applicable in the final product inspection of Na diclofenac raw materi al.
Keywords :
Diclofenac Na , Precursors , Impurities , HPLC
