Title of article
Gelatin Microspheres for the Controlled Release of All-trans-Retinoic Acid Topical Formulation and Drug Delivery Evaluation
Author/Authors
Dinarvand, Rasool Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran , Rahmani, Elham Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran , Farbod, Efat Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran
Pages
4
From page
47
To page
50
Abstract
A topical o/w cream containing tretinoin microspheres was prepared. Gelatin microspheres of
tretinoin were prepared using coacervation method. These microspheres contained about 50% w/w
tretinoin. The particle size range of microspheres was between 90-150 μm. In vitro drug release
from microspheres and a cream formulation was studied. It was shown that drug release from
microspheres followed Higuchi kinetics of release. However, drug release from the cream
formulation followed zero order release profile
Keywords
All-trans-retinoic acid , Tretinoin , Microencapsulation , Gelatin Microspheres , Coacervation , Zero order release , Topical cream
Journal title
Astroparticle Physics
Serial Year
2003
Record number
2447337
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