Author/Authors :
Jahangiri, Alireza Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran , Shafiee, Abbas Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran , Jalalizadeh , Hassan Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran , Mahmoudian ,Masoud Department of Pharmacology, Faculty of Medicine, Iran University of Medical Sciences, Tehran
Abstract :
There are many evidences that human serum paraoxonase activity modifies plasma lipid
profile and paraoxonase has an antiatherogenic property. Non-selective beta-blockers affect
plasma lipid profile too, but they have atherogenic property when patients take these drugs in
long term. In this study the effect of propranolol, a non-selective beta-blocker, on paraoxonase
activity was investigated. Lineweaver-Burk and secondary plots were drawn and showed that
propranolol is a mixed non-competitive inhibitor of paraoxonase
