Validation of Transcutaneous Bilirubin in Comparison with Serum Bilirubin for the Detection of Hyperbilirubinemia in Neonates

Background: Neonatal hyperbilirubinemia is a common and dangerous complication that should be diagnosed as soon as possible. This study aimed to validate transcutaneous bilirubin in comparison with serum bilirubin for the detection of hyperbilirubinemiain neonates. Methods: This cross-sectional study was conductedin 280 infants with jaundice who were referred to Bahar Hospital in Shahroudin 2016. The serum bilirubin was measured by the photometric method. Three measurements of transcutaneous bilirubin were performed (by Bilichek) for each infant, and their average was recorded. The sensitivity and specificity of transcutaneous bilirubin measurements were assessed in comparison with themeasurements usinglaboratory methods asthegold standard using ROC analysis. Results: Of the 280 neonates, 153 (54.6%) were male. The mean age of the patients was 11.77±4.6 days. The mean bilirubin level was 16.9±10.1 mg/dl measured usingthe BiliChekmethodand 15.3±9.5 mg/dl using the laboratory method, and the difference was significant(P<0.04). The sensitivity andspecificity of the BiliChek measurements in neonates were 88.3% and 73.6%, respectively. According to the findings from the ROC curve, the cutoff pointwas determined to be more than 14.7 units (surface area below the curve (AUC)=87.5%). Conclusions: The results of this study showed that the accuracy (sensitivity and specificity) of the BiliChek device was good and can be used to measure the neonatal bilirubin.