Molecular iodine-catalyzed combinatorial library synthesis of 2-amino-3-cyano-4H-pyran derivatives at ambient temperature

An efficient and simple synthesis of some 2-amino-3-cyano-4H-pyran derivatives was developed via the one-pot and three-component reaction of aldehydes, ethyl acetoacetate, and malononitrile in the presence of ammonium acetate at room temperature using catalytic amount of iodine. The key advantages of this method are the easy access to various substituted 2-amino-3-cyano-4H-pyran derivatives, short reaction times and high yields.