Mathematical Analysis of Drug Release for Gastrointestinal Targeted Delivery Using β-Lactoglobulin Nanoparticle

To answer challenge of targeted and controlled drug release in oral delivery various materials were studied by different methods. In the present paper, controlled metal based drug (Pd(II) complex) release manner of β‑Lactoglobulin (βLG) nanoparticles was investigated using mathematical drug release model in order to design and production of a new oral drug delivery system for gastrointestinal (GI) tract. The βLG nanoparticles containing Pd(II) complex were fabricated in the presence of low methoxyl pectin (LMP) at different conditions. Characterization of βLG nanoparticles using dynamic light scattering (DLS) and atomic force microscopy (AFM) were performed. The in vitro drug release studies were carried out at 37 °C during 8 h in the simulation conditions of GI fluid. The obtained results were fitted in various kinetically release models. The KorsmeyerPeppas model was evaluated the best describe of each simulation conditions such results indicated an anomalous diffusion manner for drug release. The release data were fitted to the Kopcha model then, using statistically evaluation revealed that βLG nanoparticlesLMP complex contain Pd(II) complex dramatically sensitive to pH. In addition, results indicated that for drug release from βLG nanoparticles delivery system erosion is predominate. So, the erosioncontrolled is drug release mechanism of this delivery system. We concluded that βLG nanoparticles complex with LMP based on mathematical drug release model would be a targeted and practical promising device for GI drug delivery.