Title of article :
Convenient One-pot Access to Pyrano[2,3-d]pyrimidine Derivatives via a CuCl2.2H2O Catalyzed Knoevenagel-Michael Addition Reaction in Water/Ethanol Media
Author/Authors :
Maghsoodlou, M.T Department of Chemistry - Faculty of Science - University of Sistan and Baluchestan - Zahedan , Mohamadpour, F Department of Chemistry - Faculty of Science - University of Sistan and Baluchestan - Zahedan , Lashkari, M Faculty of Sciences - Velayat University, Iranshahr , Hazeri, N Department of Chemistry - Faculty of Science - University of Sistan and Baluchestan - Zahedan
Abstract :
Convenient procedure for the synthesis of corresponding pyrano[2,3-d]pyrimidine derivatives were developed via one-pot
three-component reaction of aryl aldehyde derivatives, malononitrile with barbituric acids in the presence of copper(II) chloride dihydrate
(CuCl2.2H2O) as highly efficient Lewis acid catalyst. This protocol has advantages such as including a readily and inexpensive catalyst,
high reaction yields, eco-friendly solvent and high atom-economy.
Keywords :
Sustainable procedure , Copper(II) chloride dihydrate (CuCl2.2H2O) , Water/ethanol media , Pyrano[2,3-d]pyrimidine derivatives , One-pot reaction
Journal title :
Astroparticle Physics
