Author/Authors :
Dashti, Saeedeh Research and Clinical Center for Infertility - Yazd Reproductive Sciences Institute - Shahid Sadoughi University of Medical Sciences , Aflatoonian, Abbas Research and Clinical Center for Infertility - Yazd Reproductive Sciences Institute - Shahid Sadoughi University of Medical Sciences , Tabibnejad, Nasim Research and Clinical Center for Infertility - Yazd Reproductive Sciences Institute - Shahid Sadoughi University of Medical Sciences
Abstract :
Background: The goal of this study was to investigate oocyte maturation, fertilization and pregnancy rates among
infertile women, by concomitant follicle stimulating hormone (FSH) administration at the time of human chorionic
gonadotropin (hCG) trigger, compared to hCG trigger alone.
Materials and Methods: In this prospective randomized controlled trial, 109 infertile women between the ages of
20 and 40 years, received gonadotropin-releasing hormone (GnRH) antagonist and fresh embryo transfer. Following
the procedure, the subjects were randomly divided into two groups on the oocyte-triggering day. In the experimental
group, final oocyte maturation was achieved by 5000 IU hCG plus 450 IU FSH. In the control group, however, oocyte
triggering was performed by 5000 IU hCG, only. The primary outcome was clinical pregnancy and the secondary outcomes
included oocyte recovery rate, oocyte maturity rate, fertilization proportion rate, fertilization rate, implantation
rate and chemical pregnancy rate.
Results: Fifty-four women were appointed to the group with the FSH bolus injection at the time of hCG trigger and
55 women were assigned to the hCG alone group. Women in the FSH group had a significantly higher metaphase II
(MII) oocyte (7.17 ± 3.50 vs. 5.87 ± 3.19), 2 pronuclear embryos (2PNs) (5.44 ± 3.20 vs. 3.74 ± 2.30) and total embryos
(4.57 ± 2.82 vs. 3.29 ± 2.13) compared to hCG alone group, respectively. Furthermore, fertilization rate (0.75
± 0.19 vs. 0.68 ± 0.25), implantation rate (14.2 vs. 8.5%) as well as clinical (27.9 vs. 15.9%) and chemical (32.6 vs.
20.5%) pregnancy rates were higher in the FSH group, but no statistically significant difference was found (P>0.05).
Conclusion: Combination of FSH and hCG for oocyte triggering improves oocyte maturity and fertilization proportion
rates without increasing the chance of implantation, chemical and clinical pregnancy rates (Registration number:
IRCT2017082724512N5).
