IgA Vasculitis in Henoch-Schönlein Purpura

Henoch-Schönleinpurpura (HSP) is a small-vessel vasculitis formed by palpable purpura on the lower extremities (mainly on distal parts) and IgA-dominant immune complex deposition within the wall and lumen of dermal vessels in the lesions. This problem is associated with joint, gastrointestinal and renal involvement, although the level and severity of involvement may be variable. HSP also termed IgA vasculitis (IgAV), is a systemic vasculitis with an outstanding cutaneous involvement. Most patients receive only supportive therapy with hydration and rest and symptomatic relief of pain with analgesics. The vast majority of patients with HSP recover spontaneously. The course of renal diseases, diagnosis and the management are discussed in this review.