Author/Authors :
Rahman, Habibur Department of Pediatric Nephrology - Bangabandhu Sheikh Mujib Medical University Dhaka, Bangladesh. 2Associate professor, Department of Pediatric Nephrology - Bangabandhu Sheikh Mujib Medical University Dhaka, Bangladesh , Huque, Saimul Department of Pediatric Nephrology - Bangabandhu Sheikh Mujib Medical University Dhaka, Bangladesh. 2Associate professor, Department of Pediatric Nephrology - Bangabandhu Sheikh Mujib Medical University Dhaka, Bangladesh , Rahman, Azizur Department of Pediatric Nephrology - Bangabandhu Sheikh Mujib Medical University Dhaka, Bangladesh. 2Associate professor, Department of Pediatric Nephrology - Bangabandhu Sheikh Mujib Medical University Dhaka, Bangladesh , Muinuddin, Golam Department of Pediatric Nephrology - Bangabandhu Sheikh Mujib Medical University Dhaka, Bangladesh. 2Associate professor, Department of Pediatric Nephrology - Bangabandhu Sheikh Mujib Medical University Dhaka, Bangladesh
Abstract :
The clinical outcome of patients with Frequent
Relapse Nephrotic Syndrome (FRNS) or Steroid Dependent
Nephrotic Syndrome (SDNS) treated with cyclophosphamide or
cyclosporine (CsA) is yet to be established. This study was carried
out to compare the efficacy of CsA with cyclophosphamide in
patients with FRNS or SDNS.
Materials and Methods: A total of 54 FRNS or SDNS children
were randomly enrolled in this prospective study from August
2013 to July 2014. All the study subjects were treated with
prednisolone 60 mg/m2 /day until the patients were in remission
for three consecutive days. The patients were then randomly
divided into two groups (Group-A & Group-B). Group-A was
treated with cyclophosphamide at a dose of 2.5 mg/kg/day for 60
days, along with tapering dose prednisolone for 8 weeks. The
Group-B study population was treated with cyclosporine at a dose
of 3 mg/kg/day for 6 months or longer along with tapering dose of
alternate day prednisolone for the initial 8 weeks. Four patients in
Group-B and one patient in Group-A did not continue the
treatment. So, we followed-up 49 children during this period.
Results: The ef
Keywords :
Cyclosporine , Cyclophosphamide , Nephrotic syndrome , Child
