Author/Authors :
Zand, V Department of Otolaryngology - Head and Neck Surgery - Otorhinolaryngology Research Center - Shahid Sadoughi University of Medical Sciences, Yazd , Meybodian, M Department of Otolaryngology - Head and Neck Surgery - Otorhinolaryngology Research Center - Shahid Sadoughi University of Medical Sciences, Yazd , Baradaranfar, MH Department of Otolaryngology - Head and Neck Surgery - Otorhinolaryngology Research Center - Shahid Sadoughi University of Medical Sciences, Yazd , Vaziribozorg, S Department of Otolaryngology - Head and Neck Surgery - Otorhinolaryngology Research Center - Shahid Sadoughi University of Medical Sciences, Yazd , Mirzade, FS Department of Internal Medicine - Shahid Sadoughi University of Medical Sciences, Yazd , Doosti, M Infectious and Tropical Diseases Research Center - Shahid Sadoughi University of Medical Sciences, Yazd , Mandegari, M Department of Otolaryngology - Head and Neck Surgery - Otorhinolaryngology Research Center - Shahid Sadoughi University of Medical Sciences, Yazd , Mirzade, M Department of Otolaryngology - Head and Neck Surgery - Otorhinolaryngology Research Center - Shahid Sadoughi University of Medical Sciences, Yazd
Abstract :
Background and Aims: Sudden sensorineural hearing loss (SSNHL) is a common disorder
diagnosed in otologic and audiologic practices. Its accompanying symptoms include tinnitus,
dizziness, and permanent hearing loss affecting negatively the life quality of affected patients.
Many viruses have been involved in the occurrence of SSNHL especially Herpes simplex
virus (HSV) type I and II. This study was attempted to explore the association between
SSNHL and HSV infection using RT-PCR.
In this case- control study, 56 patients with SSNHL occurring within a 72-hr period were
selected as case group and 56 participants who had no recent history of this disease were
assigned into control group. Applying real-time PCR, we tracked the genome of the HSV
virus and measured its loading.
Control group comprised of 31 (55.4%) male and 25 (46.6%) female and the case group
included 26 (46.4%) male and 30 (53.6%) female. The genomic DNA of HSV was measured
by Real-time PCR in both groups, and no viral genome was detected.
The findings of the current investigation suggest no relation between HSV and SSNHL.
Further research conducting on larger population is recommended to obtain more detailed
results.
