Author/Authors :
Tanideh, Nader Stem Cells Technology Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Zarifi, Fariba School of Medicine - Shiraz University of Medical Sciences, Shiraz, Iran , Rafiee, Shima School of Medicine - Tehran University of Medical Sciences, Tehran, Iran , Khastkhodaei, Maryam Department of Anatomical Sciences - School of Medicine - Shiraz University of Medical Sciences, Shiraz, Iran , Koohi Hosseinabadi, Omid Laboratory Animals Center - Shiraz University of Medical Sciences, Shiraz, Iran , Tarkesh, Firoozeh Department of Clinical Nutrition - School of Nutrition and Food Sciences - Shiraz University of Medical Sciences, Shiraz, Iran , Kherad, Zahra Department of Mycology - School of Medicine - Shiraz University of Medical Sciences, Shiraz, Iran , Mojahed Taghi, Maryam Department of Pharmacology - School of Medicine - Shiraz University of medical sciences, Shiraz, Iran , Kamali, Mahsa Shiraz University of Medical Sciences, Shiraz, Iran , Shekarkhar, Golsa Pathology Department - Molecular Pathology - Shiraz University of Medical Sciences, Shiraz, Iran , Jahromi, Mohamad Medical Division - Dasman Diabetes Institute, Dasman, Kuwait , Zarifi, Farzane Legal Medicine Research Center - Legal Medicine Organization of Iran, Tehran, Iran
Abstract :
Background: Cisplatin is a cytotoxic agent in cancer therapy. Nephrotoxicity is considered as
a side effect of cisplatin usage. Using rate models, we studied the possible protective impact
of corn-silk (CS) extract against cisplatin-induced nephrotoxicity. Materials and Methods:
Thirty-five experimental rats were divided into five groups (n=7 per each group) as follow:
C1: Control received distilled water only; C2: received one dose of cisplatin, and CS: received
300 mg/kg/day of CS. Both CS1 and CS2 received 200 and 300 mg/kg/day of the CS extract
orally, individually, for eight consecutive days. CS1 and CS2 received a single dose of cisplatin
on the first day only. The specific biochemical markers and histopathological alterations were
evaluated. Result: According to our results, cisplatin administration could have induced severe
degeneration in all parts of the nephron tubules and liver. Pre-treatment with CS exhibited a significant
decrease in the malondialdehyde (MDA) levels as compared to the values obtained after
treatment with cisplatin alone (P<0.01). Moreover, the CS extract with 200 mg dose showed
significant (P<0.01) protection against the cisplatin-induced elevation of blood urea nitrogen.
Further, the serum levels of alanine transaminase and aspartate transaminase were higher in the
cisplatin-treated groups, when compared to the control group (P<0.05). Furthermore, the hepatic
function was also improved in cisplatin-treated animals, which were pre-treated with CS.
Conclusion: CS has the potential to attenuate nephrotoxicity and lipid peroxidation induced by
cisplatin in rats.
