The Study of Relationship between Serum Levels of Soluble fmslike Tyrosine Kinase1 and Soluble Fibrinogenlike Protein 2 with Delayed Graft Function after Kidney Transplantation

Delayed graft function (DGF) is a transplant complication which means a need to dialysis throughout the first week after transplantation. This study aimed to ascertain the relationship between the two immunomodulatory factors of soluble fmslike tyrosine kinase1 (sFlt1) and soluble fibrinogenlike protein 2 (sFGL2) with DGF after transplantation. This casecontrol study was done in 2 groups of 58 kidney transplant patients with and without DGF. The control group included the patients who didn #x2019;t show DGF symptoms. Then, serum levels of sFlt1and sFGL2 in all blood samples were measured by ELISA. Serum sFlt1 and sFGL2 levels were significantly higher in the DGF group compared to those in the control group (p #x2264;0.001). sFlt1 and sFGL2 serum levels significantly affect DGF (p lt;0.001) in such a way that they may be diagnostic factors of DGF. This study showed a significant relationship between sFlt1 as well as sFGL2 and DGF. Therefore, plasma levels of sFlt1 and sFGL2 may be used as diagnostic tools to determine the risk of DGF.