Comparative Evaluation of the Biochemical Effects of Ketamine plus Ketoprofen and Midazolam in the Premedication of Pigeons

The present study was conducted with the aim of comparing the effects of premedication with ketoprofen and midazolam in birds. A total of 24 male pigeons with an approximate weight of 300 g were divided into four equal groups. The control group (Group I) was injected with ketamine alone. Groups II-IV were injected with ketoprofen alone, ketoprofen+ketamine, and midazolam+ketamine, respectively. The biochemical changes in the four groups were evaluated after intramuscular drug injections at different anesthetic levels. A record of biochemical changes was maintained for each group. Blood samples were taken before and after the administration of the medications in order to measure the levels of serum alkaline phosphatase (ALP), oxaloacetate transaminase (OT), prothrombin time (PT), glucose (GLU), lactate dehydrogenase (LDH), albumin (Alb), total protein (TP), and gamma-glutamyl transferase (GGTF). The results showed significant differences in the mean levels of ALP, OT, PT, GLU, LDH, Alb, and TP after anesthesia, compared to that before anesthesia. Therefore, ketoprofen+ketamine can be used for the induction of anesthesia in birds.