Synthesis of methyl 2-[2-(alkylimino)-4-oxo-3-phenyl- 1,3-thiazolan-5- yliden]acetate derivatives under solvent-free condition

An efficient synthesis of Methyl 2-[2-(alkylimino)-4-oxo-3-phenyl-1,3-thiazolan-5- yliden]acetate derivatives via simple three-component reaction and one-pot reactions between isoquinoline, dimethyl acetylenedicarboxylate and N-phenylthiourea is described under solvent-free conditions without using any additional catalyst.