Title of article :
One-pot synthesis of highly regioselective β-azido alcohols catalyzed by Brønsted acidic ionic liquids
Author/Authors :
Mohammadi-Aghdam ، Sarvin - Payame Noor University , Jabbari ، Hadi - Payame Noor University , Pouralimardan ، Omidali - Payame Noor University , Divsar ، Fater - Payame Noor University , Amini ، Issa - Payame Noor University , Sajjadifar ، Sami - Payame Noor University
Abstract :
In this protocol, 3-(2-carboxybenzoyl)-1-methyl-1H-imidazol-3-ium chloride [Cbmim]Cl and sulfonic acid functionalized pyridinium chloride [pyridine-SO3H]Cl as a new, reusable, and green Brønsted acidic ionic liquid (BAIL) catalyst were synthesized and successfully used for the one-pot ring-opening of epoxide with sodium azide (NaN3) in water at room temperature. Epoxides undergo ring-opening readily with NaN3 in the presence of [Cbmim]Cl and [pyridine-SO3H]Cl to afford the corresponding β-azido alcohols as attractive and interesting materials in drug design and pharmaceutics compounds in high yield with good regioselective under mild reaction conditions.
Keywords :
[Cbmim]Cl , [pyridine , SO3H]Cl , epoxide , ring opening , Azidoalcohols , water
Journal title :
Iranian Chemical Communication
Journal title :
Iranian Chemical Communication
