Synthesis and anti-microbial activities of azomethine and aminomethyl phenol derivatives

A series of azomethine and aminomethyl phenol derivatives was synthesized, and characterized using mass, IR, and NMR spectral techniques. In vitro antimicrobial activities of the compounds were evaluated against different gram-positive and gram-negative bacterial and fungal strains by measuring zone of inhibition using agar diffusion method. Results of the antimicrobial screening indicated that the compound 4a was the most active antimicrobial agent (100 μg/mL). The compounds 3a, 4e, 4f were exhibited best in vitro anti-microbial activity against the gram positive bacterial strains such as Bacillus subtilis, Micrococcus luteus and gram negative bacterial strain Salmonella typhi, and fungal strain Candida albicans.