Title of article
The IRX3 Gene; the Missing Link between the FTO Gene and Obesity
Author/Authors
Doaei ، Saeid - Shahid Beheshti University of Medical Sciences , Gholamalizadeh ، Maryam - Shahid Beheshti University of Medical Sciences , Mosavi Jarrahi ، Alireza - Shahid Beheshti University of Medical Sciences , Badakhanian ، Marjan - Isfahan University of Medical Sciences , Najafi ، Rahim Urmia University of Medical Sciences
Pages
3
From page
33
To page
35
Abstract
Aims: The aim of this study was the investigation of the mediator role of the IRX3 gene in the relationship between the FTO gene and obesity. Materials and Methods: All related articles published in English from June 1990 to February 2017 were studied. Results: Only a Few studies have examined the association between the IRX3 gene with the FTO gene and obesity. However, all of them reported that the FTO gene can influence the IRX3 gene expression. Also, it’s reported that the IRX3 gene expression level has a significant association with body weight and body composition. Conclusions: The FTO gene effects on obesity is in part due to its impact on the IRX3 gene expression level. The further studies are needed to investigate this interaction and clarify the existing mechanisms
Keywords
IRX3 gene , the FTO gene , obesity
Journal title
Asian Pacific Journal of Cancer Biology
Serial Year
2016
Journal title
Asian Pacific Journal of Cancer Biology
Record number
2461576
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