Association study of calpain-10 gene polymorphism in patients with polycystic ovarian syndrome

Polycystic Ovarian syndrome (PCOSS) is a common endocrine disorder with prevalence of 510% globally among women of reproductive age. PCOSS is being characterized by chronic anovulation , polycystic ovaries, hyperandrogenism, hirsutism, overweight, insulin resistance and infertility. It is wellknown that PCOSS is a complex trait alike to Type2 Diabetes where both genetic and environmental factors play a crucial role in pathogenesis of the disease. A couple of Type2 Diabetes susceptibility genes including those for insulin secretion and action such as Calpain10 showed considerable contribution to genetic predisposition of PCOSS. Since Calpain10 gene seems to be a strong candidate gene to PCOSS, we aimed to investigate the role of Caplain10 gene polymorphism UCSNP44 (T/C) located in a transcription enhancer element of the gene to the disease susceptibility. We carried out a crosssectional casecontrol study. Using simple random sling ninety healthy women were selected. All ninety patients fulfilled the 2003 Rotterdam criteria of PCOSS. The subjects were genotyped for Caplain10 gene polymorphism UCSNP44 (T/C) using PCRRFLP. Differences in genotype distributions between case and control subjects were examined via a chisquare test. Although PCOSS showed high prevalence among women in Bandar Abbas city, Caplain10 gene polymorphism UCSNP44 (T/C) UCSNP44 doesn׳ t influence susceptibility to PCOSS.