The Association of 4G/5G Polymorphism of PAI-1-675 Gene with Clinicopathologic Features of Thyroid Tumors in Iranian Azeri Turkish Patients

Background: Due to the lack of information about the role of 4G/5G polymorphism of PAI-1 Gene in susceptibility to thyroid tumors, this study was performed to evaluate the potential effects of this polymorphism on clinicopathologic features of thyroid tumors in Iranian Azeri Turkish patients. Methods: In this case-control study, 90 patients with thyroid tumors who were not blood relatives and their PAI-1 4G/5G polymorphism had been determined in the previous study, were included. Results: All clinicopathologic features of thyroid tumor related to PAI-1 4G/5G polymorphism that affect the severity of disease were studied. The results show that T1 tumor size (4G/4G, P = 0.019; 4G/5G, P = 0.021) in patients with/without these features was significantly different. Conclusion: Data showed a protective role for 4G allele versus 5G and 4G/4G versus 5G/5G against the development of thyroid tumors in Azeri Turkish ethnic group.