Author/Authors :
YOU ، Dingyun - Kunming Medical University , LU ، Nanjia - Ningbo University , DUAN ، Donghui - Ningbo University , LI ، Hui - Institute of Non-Communicable Disease Control and Prevention , XING ، Wenhua - Ningbo University
Abstract :
Background: Glutathione S-transferases (GSTs) have been investigated as potential carcinoma susceptible genes. However, the relationship between GSTs (GSTM1, GSTT1) variants and gastric carcinoma (GC) risk has been controversial in Chinese population. Methods: A comprehensive literature search strategy (PubMed, Chinese Biomedical Database, Chinese National Knowledge Infrastructure, Wan fang Database, etc.) was launched. Crude odds ratios (ORs) and confidence intervals (95% CI) were applied to estimate the strength of the association. Results: Significant associations between GSTs genetic polymorphisms and GC were evidenced under random-effects model (ORGSTM1=1.56, 95% CI: 1.39 to 1.76, I2=50.7%, P 0.0001; ORGSTT1=1.24, 95% CI: 1.10 to 1.39, I2=43.6%, P=0.014; ORGSTM1-GSTT1=1.51, 95% CI: 1.26 to 1.81, I2=59.7%, P=0.004). The pooled ORs were not quali-tatively changed when any single study was omitted by sensitivity analysis. Conclusion: Our results indicated an increased GC risk in Chinese population with GSTM1 and GSTT1 null geno-type and GSTM1-GSTT1 dual null genotype. Further multi-center studies are needed to investigate the gene-gene and gene-environment interactions on the susceptibility of GC.
