The Effect of High Intensity Interval Training and Herb Supplement on Heart IGF1 Concentration in Male Rat

Introduction: The objective of the present study was to determine the effect of 10 weeks of highintensity interval training (HIIT) and flaxseed oil supplement on heart IGF1 concentration in male rats. Methods: Twenty adult male Wistar rats were randomly divided into saline, saline–training, supplementation, and supplementation–training groups. The training groups performed training (10 weeks, 5 sessions per week, 90%–95% VO2 max) on a rodent treadmill. The supplementation groups received flaxseed oil supplement (300 mg/kg). The rats were sacrificed 5 days after the last training session. The heart tissue was collected, and insulinlike growth factor1 (IGF1) was measured in the heart tissue. Results: Training increased the concentration of the heart IGF1 (P=0.01). The concentration of heart IGF1 was higher in the flaxseed oilsupplemented group than the salinetreated groups. (P=0.003). The interaction between training and supplementation also led to an increase in heart IGF1 concentration (P=0.001). Conclusion: The increase of heart IGF1 in trained supplemented group suggests that training and flaxseed oil can help to improve cardiac function.