Title of article :
The Contribution of Gene Mutations to the Pathogenesisof Tetralogy of Fallot
Author/Authors :
Safari-Arababadi ، Amin - Fars Science and Research Branch, Islamic Azad University , Behjati-Ardakani ، Mostafa - Shahid Sadoughi University of Medical Sciences , Kalantar ، Seyed Mehdi - Shahid Sadoughi University of Medical Sciences , Jaafarinia ، Mojtaba - Fars Science and Research Branch, Islamic Azad University
Abstract :
Congenital heart disease (CHD) is considered as an important and developing area in the medical community. Since these patients can reach maturity and have children, the role of genetic determinants in increasing risk of CHD is extremely evident among children of these patients. Because genetic studies related to CHD are increasing, and each day the role of new genetic markers is more and more clarified, this review reexamined the effects of gene mutations in the pathogenesis of tetralogy of Fallot (TOF) as an important pathological model among other CHDs. Due to the complexity of heart development, it is not astonishing that numerous signaling pathways and transcription factors, and many genes are involved in pathogenesis of TOF. This review focuses on the jag1, nkx2.5, gata4, zfpm2/fog2 and cited2 genes previously reported to be involved in TOF.
Keywords :
Congenital heart disease , Tetralogy of Fallot , Gene mutation
Journal title :
International Journal of Basic Science in Medicine
Journal title :
International Journal of Basic Science in Medicine
