Comparison of serum total antioxidant capacity between subjects with and without metabolic syndrome according their body mass index

Background: This study aimed to determine the differences in plasma total antioxidant capacity between metabolic syndrome patients and those without metabolic syndrome with normal weight, overweight, and obesity. Methods: A casecontrol study was carried out among 146 men and women (aged 2055 years) in Endocrinology Center of Tehran University of Medical Sciences. The case group included overweight/obese subjects with metabolic syndrome and the two control groups were weightmatched subjects without metabolic syndrome and normal weight subjects without metabolic syndrome. Total antioxidant capacity was determined using the colorimetric method. Results: Waist circumference and total antioxidant capacity of the case group were significantly higher than that of both control groups ((p lt;0.001) for both). There was no significant difference between normal and overweight/obese control groups in total antioxidant capacity level (p=0.53). Conclusion: Oxidative stress presumably is an important factor in the pathology of metabolic syndrome and total antioxidant capacity may be responsible for defense against oxidants.