Title of article
In vitro Anticancer Evaluation of Saponins Obtained From Spirulina platensis on MDA, HepG2, and MCF7 Cell Lines
Author/Authors
Akbarizare ، Mahboobeh - Iranian Research Organization for Science and Technology (IROST) , Ofoghi ، Hamideh - Iranian Research Organization for Science and Technology (IROST) , Hadizadeh ، Mahnaz - Iranian Research Organization for Science and Technology (IROST)
Pages
8
From page
25
To page
32
Abstract
Introduction: Microalgae are known for their bioactive compounds with potential applications as antimicrobial, antiaging, and anticancer activities. Spirulina platensis (S. platensis) is a filamentous and photosynthetic microorganism that has 25 kinds of vitamins and minerals that contain many compounds with biotic activity such as alkaloids, phenolic compounds, terpenoids, and saponins. Saponins are mainly present in plants; while there are few studies about their role in microalgae. This study aims to investigate the anticancer potential of extracted saponins from S. platensis. Methods: Saponins were extracted; using distilled water and n-butanol. The total extracted saponin was dried and weighed. The cellular viability of HepG2, MCF-7, and MDAMB-123 cell lines was evaluated; using MTT assay after 24 h treatment with 0.02-2 mg/ml of saponins extracted from S. platensis. Morphology of cell lines was evaluated by invert microscopy.
Keywords
Microalgae , Antineoplastic Agents , Saponins , Spirulina , Chromatography , Thin Layer
Journal title
Multidisciplinary Cancer Investigation
Serial Year
2019
Journal title
Multidisciplinary Cancer Investigation
Record number
2469731
Link To Document