Author/Authors :
Huber Said, Padilla‑Zambrano Centro de Investigaciones Biomédicas - Cartagena Neurotrauma Research Group Research Line - Faculty of Medicine - University of Cartagena - Cartagena de Indias , Romario, Mendoza‑Flórez Centro de Investigaciones Biomédicas - Cartagena Neurotrauma Research Group Research Line - Faculty of Medicine - University of Cartagena - Cartagena de Indias , Boris Vladimir, Cabrera‑Nanclares Centro de Investigaciones Biomédicas - Cartagena Neurotrauma Research Group Research Line - Faculty of Medicine - University of Cartagena - Cartagena de Indias , Pal, Ranabir Department of Community Medicine - MGM Medical College and LSK Hospital - Kishanganj, Bihar , Ghosh, Amrita Department of Biochemistry - Kolkata Medical College - Kolkata, West Bengal , Deora, Harsh Department of Neurosurgery - National Institute of Mental Health and Neurosciences - Bengaluru, Karnataka , Rafael Moscote‑Salazar, Luis Neurosurgery‑Critical Care - Red Latino - Organización Latinoamericana de Trauma y Cuidado Neurointensivo - Bogota, Colombia , Agrawal, Amit Department of Neurosurgery - Narayana Medical College Hospital - Nellore - Andhra Pradesh, India
Abstract :
In this systematic review, we detailed the current understanding and controversies on venous thromboembolism as the sequel following
traumatic brain injury (TBI). The review was conducted on the literature survey to find the thromboembolic morbidities in TBI patients. This
review presented the thromboembolic sequel of patients with TBI by a comprehensive focused assembly of research publications by searching
various resources. A search strategy with specific inclusion criteria was performed in PubMed, Cochrane, Web of Science, and the WHO Global
Health Library. TBI is related with the incremental presence of spectrum of thromboembolic disorders from primary and secondary injuries
by the significant increases in the concentrations of the initiating factors of the coagulation cascade. The incidences of thromboembolism vary
on factors like the severity of TBI, methods of prophylaxis used or the processes to diagnose embolic involvement. The most effective time
for the initiation of antithrombotic therapy chemoprophylaxis should be initiated after 24 h or after 72 h in patients with brain trauma is still
a controversial issue. Patients with brain injury are at increased risk for thromboembolism for which prophylaxis and timely management are
highly recommended, and this should be available in all levels of care.
