Author/Authors :
García‑Marín, Carmen Department of Stomatology IV - School of Dentistry - Complutense University of Madrid, Madrid , Ferrer, Paula Department of Stomatology IV - School of Dentistry - Complutense University of Madrid, Madrid , Victoria Mateos, María Department of Stomatology IV - School of Dentistry - Complutense University of Madrid, Madrid , Rodríguez, Nazaret Department of Stomatology IV - School of Dentistry - Complutense University of Madrid, Madrid , de Fernando, Encarna Department of Stomatology IV - School of Dentistry - Complutense University of Madrid, Madrid , María Marín, José Department of Stomatology IV - School of Dentistry - Complutense University of Madrid, Madrid , Yanez, Rosa Department of Stomatology - School of Dentistry - University of Sevilla - Sevilla, Spain
Abstract :
Nonsyndromic unilateral permanent canine agenesis, particularly in the lower jaw, is an infrequent
clinical observation that has occasionally been reported in the scientific literature. The main aim of
the present case report and study is to give insights into the clinical features and genetic information
of a nonsyndromic patient affected by unilateral lower canine agenesis and her relatives. A young girl
of 9‑year‑old with a Class II skeletal malocclusion, sella turcica bridging, and severe overjet but no
other dental anomalies is described. No associations were found with other types of dental agenesis
and previously described genetic variations of the CTNNB1 gene. The possibility of a novel genetic
locus should be considered as a possible genetic etiology for this extremely rare condition in a
nonsyndromic patient. Based on scientific literature written in English, the present clinical case is one
of the first reports to describe a nonsyndromic permanent unilateral mandibular canine agenesis.
Keywords :
Agenesis , canine , malocclusion , orthodontics
