Author/Authors :
Alikhani, Ahmad Department of Antimicrobial Resistance Research Center - Faculty of Medicine - Mazandaran University of Medical Sciences, Sari, Iran , Babamahmoodi, Farhang Department of Antimicrobial Resistance Research Center - Faculty of Medicine - Mazandaran University of Medical Sciences, Sari, Iran , Foroutan Alizadegan, Laleh Mazandaran University of Medical Sciences, Sari, Iran , Shojaeefar, Arman Ghaemshahr Razi Hospital, Ghaemshahr, Iran , Abdolreza Babamahmoodi Health Management Research Center - Baqiyatallah University of Medical Sciences, Tehran, Iran
Abstract :
Background: A surgical site infection (SSI) is the most common nosocomial infection
after surgery and is the third most common infection in hospitalized patients. The aim of
this study was to asses minimum inhibitory concentration (MIC) of the causing agents of
SSI and antimicrobial susceptibility patterns.
Methods: This cross-sectional study was done in three referral hospitals in North of Iran
during 2011-2012. The samples were taken one month after orthopedic, abdominal,
cesarean section surgery and coronary artery bypass graft (CABG) in patients with scores
compatible to SSIs criteria. The sample was sent for bacteriologic culture and MIC
determination for positive cases by broth microdilution method. The data were collected
and analyzed.
Results: From 103 positive cases S. aureus, E.coli and coagulase negative staphylococci
were the most common isolated agents as 29.12%, 23.3% and 21.3%, respectively. S.
aureus was sensitive to vancomycin (70%), amikacin (70%) and teicoplanin (76.6%) and
cogulase negative staphylococci was sensitive to vancomycin (68.1%) and teicoplanin
(72.6%) and E.coli to amikacin (95.83%) and imipenem and meropenem (66.66%).
P.aeroginosa showed no sensitivity to cefepime and was sensitive to imipenem (93.75%)
and meropenem (81.25%).
Conclusion: The most important point is worrisome problem of the increased MIC of S.
aureus to vancomycin that causes difficult use in the treatment of staphylococcal SSIs. In
spite of resistance of micro-organisms to cephalosporins, gram negative organisms had
low MIC to carbapenemes especially P.aeroginosa although the rate of its MIC is
increasing.
Keywords :
Antibiotics , Minimal Inhibitory Concentration , Surgical site infection , Resistance