Trauma-induced Apoptosis of Endothelial Cells

Trauma is a common cause of death in the developed countries leading trauma related coagulopathy. In recent years, ‘new type endothelium development’ caused by traumainduced hemorrhagic shock, has been widely understood and researchers trying to figure out the effect of endothelial apoptosis on this process. New modulation of immune response may result in undesired apoptosis and give rise to programmed cell death. In experimental models, apoptosis has been shown in liver, kidney, heart and brain after the damage of ischemia/reperfusion (I/R) during trauma. Apoptosis may be an important factor for the development of serious hemorrhagic shock during trauma. In this review we aimed to reveal the possible relationship between trauma and apoptosis.The balance between pro-apoptotic and anti-apoptotic pathway seals; the fate of every endothelial cell. Apoptotic cell death is important in traumatic hemorrhage and sepsis. Apoptosis increases depending on the severity of hemorrhagic shock during trauma.